Biodegradation, Bioactivity and In vivo Biocompatibility Analysis of Plasma Electrolytic Oxidized (PEO) Biodegradable Mg Implants
Mehdi Razavi *
Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran and Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran and School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA and School of Electrical and Computer Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA
Mohammad Hossein Fathi
Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran and Dental Materials Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Omid Savabi
Torabinejad Dental Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
Daryoosh Vashaee
School of Electrical and Computer Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA
Lobat Tayebi
School of Materials Science and Engineering, Helmerich Advanced Technology Research Center, Oklahoma State University, Tulsa, OK 74106, USA and School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA
*Author to whom correspondence should be addressed.
Abstract
In this paper, a plasma electrolytic oxidation (PEO) coating was prepared on AZ91 magnesium (Mg) implant to improve its degradation resistance, bioactivity and biocompatibility. The phase composition and surface morphology of the samples were characterized using X-ray diffraction (XRD) and scanning electron microscope (SEM). The corrosion rate and the bioactivity behavior of the samples were investigated via electrochemical measurements and immersion tests in simulated body fluid (SBF). The biocompatibility of samples was evaluated both in vitro and in vivo. To performed in vitro examinations, L-929 cells were cultured on both coated and uncoated substrates, and for the in vivo study, samples were implanted into the greater trochanter of rabbits as our animal model. The results showed that the PEO coating enhanced the corrosion resistance and in vitro and in vivo biocompatibility of AZ91 Mg implants.
Keywords: Plasma electrolytic Oxidation, Biodegradable Mg alloy, in vitro, L-929 cells, in vivo, Biomedical applications