Synthesis, X-ray Crystallographic Studies and Antibacterial Screening of 1-(5-(4-Chlorophenyl) thiazol-2-yl) Hydrazine Hydrobromide
Published: 2013-02-13
Page: 10-17
Issue: 2013 - Volume 3 [Issue 1]
Imtiaz Khan *
Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan
Aliya Ibrar
Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan
Muhammad Waqas
Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan
Jonathan M. White
Bio-21 Institute, School of Chemistry, University of Melbourne, Parkville-3052, Australia
*Author to whom correspondence should be addressed.
Abstract
The synthesis of 1-(5-(4-chlorophenyl)thiazol-2-yl)hydrazine hydrobromide was achieved in a single step by condensation of 2-bromo-1-(4-chlorophenyl)ethanone with thiosemicarbazide in absolute ethanol. The structure of the target compound was deduced by modern spectroscopic techniques including FTIR, 1H and 13C NMR spectroscopy and unequivocally confirmed by crystallographic data. The title compound crystallized in the orthorhombic space group P 21 2 21 with unit cell parameters a = 6.6861(6) Å, b = 8.9683(12) Å, c = 20.4035(5) Å, α = β = γ = 90º, V = 1223.5(2) Å3, Z = 4, Dc = 1.751 mg/m3, F(000) = 640 and μ = 8.058 mm-1. The synthesized compound was also evaluated for antibacterial activity.
Keywords: Condensation, thiazole, crystal structure, antibacterial activity