Synthesis, X-ray Crystallographic Studies and Antibacterial Screening of 1-(5-(4-Chlorophenyl) thiazol-2-yl) Hydrazine Hydrobromide

Imtiaz Khan *

Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan

Aliya Ibrar

Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan

Muhammad Waqas

Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan

Jonathan M. White

Bio-21 Institute, School of Chemistry, University of Melbourne, Parkville-3052, Australia

*Author to whom correspondence should be addressed.


Abstract

The synthesis of 1-(5-(4-chlorophenyl)thiazol-2-yl)hydrazine hydrobromide was achieved in a single step by condensation of 2-bromo-1-(4-chlorophenyl)ethanone with thiosemicarbazide in absolute ethanol. The structure of the target compound was deduced by modern spectroscopic techniques including FTIR, 1H and 13C NMR spectroscopy and unequivocally confirmed by crystallographic data. The title compound crystallized in the orthorhombic space group P 21 2 21 with unit cell parameters a = 6.6861(6) Å, b = 8.9683(12) Å, c = 20.4035(5) Å, α = β = γ = 90º, V = 1223.5(2) Å3, Z = 4, Dc = 1.751 mg/m3, F(000) = 640 and μ = 8.058 mm-1. The synthesized compound was also evaluated for antibacterial activity.

 

Keywords: Condensation, thiazole, crystal structure, antibacterial activity


How to Cite

Khan, Imtiaz, Aliya Ibrar, Muhammad Waqas, and Jonathan M. White. 2013. “Synthesis, X-Ray Crystallographic Studies and Antibacterial Screening of 1-(5-(4-Chlorophenyl) Thiazol-2-Yl) Hydrazine Hydrobromide”. Physical Science International Journal 3 (1):10-17. https://journalpsij.com/index.php/PSIJ/article/view/201.

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